Lewisburg High School is a public four-year high school in Lewisburg, Mississippi and is a part of the DeSoto County Public Schools system. Students are exposed to a traditional course of study with emphasis on college and career readiness for post-secondary transition.

In order to meet graduation requirements, students at Lewisburg High School must complete 26 Carnegie credits from the main subject areas and electives in areas of interest. A College Preparatory Curriculum (CPC) is offered for college-bound students. Lewisburg High School reports a graduation rate of 92 percent.

Students planning to attend college have the opportunity to engage in accelerated, Advanced Placement, and Career and Technical Education courses to ensure that they are ready for college and careers upon graduation. Lewisburg High School offers 10+ Advanced Placement courses in English, mathematics, social studies, and fine arts. Students seeking to earn credits for both high school requirements and early college credits may choose to take the three Dual Credit courses that are offered by the school.